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. 2022 Mar 2;12:829502. doi: 10.3389/fonc.2022.829502

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Copyright © 2022 Vischioni, Russo, Meuli, Bonora, Ronchi, Ingargiola, Camarda, Imparato, Preda, Ciocca, Molinelli and Orlandi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment plans on the simulation CT of one of the patients of the series with ACC at the right nasal cavity with color wash of the most representative isodoses at the maxilla (contoured in blue), calculated with LEM (A) and MKM (B) radiobiological model, are shown. The irradiation geometry consisted of 2 beam ports with couch rotation of 165°C and 180°C. In (C) the DVH curves for the maxilla calculated with LEM and MKM are depicted. In (D) a T1-weighted axial image taken from the 2 years post-CIRT MRI of the same patient is depicted with typical imaging features of maxillary Grade 1 necrosis.