TABLE 1.

Activities of HMR 3004 and HMR 3647 compared to those of levofloxacin and other quinolones and macrolides against Neisseria spp. and Moraxella catarrhalis

Organism (no. of isolates) and drug	MIC (μg/ml)
	Range	50%	90%
Neisseria meningitidis (200)a
HMR 3004	0.007–0.25	0.06	0.12
HMR 3647	0.03–0.5	0.12	0.12
Erythromycin	0.06–2	1	1
Roxithromycin	0.06–4	0.5	1
Clarithromycin	0.003–1	0.12	0.5
Azithromycin	0.25–2	0.5	1
Ciprofloxacin	≤0.003–0.03	0.007	0.007
Ofloxacin	0.007–0.03	0.03	0.03
Levofloxacin	≤0.003–0.03	0.007	0.015
Sparfloxacin	≤0.003–0.015	≤0.003	0.007
Neisseria gonorrhoeae (200)b
HMR 3004	≤0.003–0.5	0.06	0.12
HMR 3647	≤0.003–0.5	0.06	0.12
Erythromycin	0.06–2	0.5	2
Roxithromycin	0.06–4	1	2
Clarithromycin	0.03–2	0.25	1
Azithromycin	0.015–0.5	0.12	0.25
Ciprofloxacin	≤0.003–0.06	≤0.003	0.007
Ofloxacin	0.007–0.25	0.03	0.06
Levofloxacin	≤0.003–0.12	0.007	0.015
Sparfloxacin	≤0.003–0.03	≤0.003	0.007
Neisseria polysaccharea (10)
HMR 3004	0.007–0.25	0.12	0.25
HMR 3647	0.007–0.25	0.12	0.25
Erythromycin	0.06–4	1	2
Roxithromycin	0.06–2	0.5	2
Clarithromycin	0.007–1	0.12	1
Azithromycin	0.03–0.25	0.06	0.25
Ciprofloxacin	≤0.003	≤0.003	≤0.003
Ofloxacin	0.007–0.015	0.007	0.015
Levofloxacin	≤0.003	≤0.003	≤0.003
Sparfloxacin	≤0.003–0.007	≤0.003	≤0.003
Neisseria lactamica (10)
HMR 3004	≤0.003–1	0.03	1
HMR 3647	0.007–0.5	0.06	0.5
Erythromycin	2–4	4	4
Roxithromycin	4–8	4	8
Clarithromycin	2–4	2	4
Azithromycin	1–2	2	2
Ciprofloxacin	≤0.003–0.007	≤0.003	0.007
Ofloxacin	0.015–0.03	0.03	0.03
Levofloxacin	≤0.003–0.015	≤0.003	0.015
Sparfloxacin	≤0.003	≤0.003	≤0.003
Neisseria mucosa (10)
HMR 3004	0.015–4	2	4
HMR 3647	0.06–4	0.5	4
Erythromycin	0.25–8	4	8
Roxithromycin	0.25–16	8	16
Clarithromycin	0.06–8	4	8
Azithromycin	0.06–8	2	8
Ciprofloxacin	≤0.003–0.007	0.007	0.007
Ofloxacin	0.015–0.06	0.03	0.06
Levofloxacin	0.007–0.03	0.015	0.03
Sparfloxacin	≤0.003–0.015	≤0.003	0.007
Neisseria cinerea (10)
HMR 3004	0.015–1	0.5	1
HMR 3647	0.015–1	0.5	1
Erythromycin	1–8	4	8
Roxithromycin	2–8	8	8
Clarithromycin	0.5–4	4	4
Azithromycin	0.5–4	2	2
Ciprofloxacin	≤0.003–0.12	0.007	0.015
Ofloxacin	0.015–0.25	0.03	0.06
Levofloxacin	0.007–0.12	0.015	0.03
Sparfloxacin	0.007–0.015	0.007	0.015
Neisseria perflava/sicca (10)
HMR 3004	0.03–4	0.5	4
HMR 3647	0.06–4	0.5	4
Erythromycin	0.5–16	8	8
Roxithromycin	1–16	8	16
Clarithromycin	0.25–16	4	8
Azithromycin	0.25–4	4	4
Ciprofloxacin	≤0.003–0.06	0.015	0.03
Ofloxacin	0.015–0.12	0.06	0.12
Levofloxacin	≤0.003–0.12	0.03	0.03
Sparfloxacin	≤0.003–0.03	0.007	0.03
Moraxella catarrhalis (150)c
HMR 3004	0.06–0.25	0.12	0.12
HMR 3647	0.06–0.25	0.12	0.12
Erythromycin	0.06–0.5	0.25	0.25
Roxithromycin	0.12–1	0.5	0.5
Clarithromycin	0.03–0.25	0.12	0.12
Azithromycin	0.015–0.12	0.06	0.06
Ciprofloxacin	0.015–0.12	0.06	0.06
Ofloxacin	0.06–0.5	0.06	0.06
Levofloxacin	0.03–0.12	0.06	0.06
Sparfloxacin	≤0.003–0.06	0.015	0.03

^aNeisseria meningitidis isolates include 50 penicillin-susceptible–rifampin-susceptible strains, 15 strains susceptible to penicillin and moderately resistant to rifampin, 5 strains moderately resistant to penicillin and resistant to rifampin, 100 strains moderately resistant to penicillin and susceptible to rifampin, and 30 strains moderately resistant to rifampin and to penicillin. 

^bNeisseria gonorrhoeae isolates include 56 penicillin-susceptible strains, 10 strains moderately resistant to penicillin (β-lactamase negative), 64 penicillin-resistant (chromosomic) strains, and 70 penicillin-resistant (β-lactamase-positive) strains. 

^c Moraxella catarrhalis isolates include 120 β-lactamase-producing and 30 β-lactamase-nonproducing strains.