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. 2022 Mar 2;9:760722. doi: 10.3389/fmed.2022.760722

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Copyright © 2022 Zhang, Zhang, Zhao, Xiao, Liu, Peng, Jiang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Heatmap for the co-expression of 9 pyroptosis-related prognostic lncRNAs with NLRP6. (B) Histogram for NLRP6 mRNA different expression between low-and high-risk groups. (C) Histogram for NLRP6 different expression between normal and tumor tissues based on LIHC-TCGA database. (D) Validation of the expression of NLRP6 on the translational level by the Human Protein Atlas database (immunohistochemistry, IHC), scale bar = 200 μm. (E) Representative IHC images for NLRP6 performed on the tissues from one HCC patient. (1, 3) Scale bar = 2 μm, (2, 4) scale bar = 0.5 μm. (F) Kaplan-Meier survival curves for the overall survival (OS) based on low/high expression of NLRP6 separated by the median expression. (G) Bubble graph for the co-expression of NLRP6 and TP53. (H) Relationship between NLRP6 expression and infiltration levels of immune cells in HCC via the TIMER database. (I) Kaplan-Meier curves revealed the immune infiltration and overall survival rate of HCC. **P < 0.01, ***P < 0.001.