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. 2022 Mar 2;16:838335. doi: 10.3389/fnins.2022.838335

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Copyright © 2022 Monfort, Want, Gervason and D’Autréaux.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mapping iron-binders amino acids of frataxin (FXN) within the NFS1-ISD11-ACP-Zn-ISCU-FXN complex. Structure of the human NFS1-ISD11-ACP-Zn-ISCU-FXN complex (PDB code 6NZU) highlighting the amino acids of FXN identified as iron-binders. The amino acids interacting with NFS1 (E96, E100, E108, E111, D115, E121, and D124) or important for the internal structure of FXN (E92, E101) are colored in pink and those not interacting with other amino acids (D104 and D112) are in cyan. ISCU is colored in salmon, the two subunits of the NFS1 dimer are in light green (NFS1) and dark green (NFS1’), FXN is in blue.