TABLE 1.

Impact of cardiac conduction-focused annotation project.

GO term identifier	GO term	Number of annotations March 2021		Number of annotations October 2020
		All	Priority	All	Priority
GO:0003161	Cardiac conduction system development	17 (Gros et al., 2010)	17 (Gros et al., 2010)	3 (van Weerd and Christoffels, 2016)	3 (van Weerd and Christoffels, 2016)
GO:0003162	Atrioventricular node development	9 (Mommersteeg et al., 2007)	7 (Hoogaars et al., 2007)	2 (Kennedy et al., 2016)	0
GO:0003163	Sinoatrial node development	13 (Tessadori et al., 2012)	12 (Puskaric et al., 2010)	1 (Kennedy et al., 2016)	0
GO:0003164	His-Purkinje system development	10 (Hoogaars et al., 2007)	9 (Wiese et al., 2009)	1 (Kennedy et al., 2016)	0
Total number of CCS development annotations		49 (Richardson and Bult, 2015)	45 (Balakrishnan et al., 2013)	7 (Wiese et al., 2009)	3 (van Weerd and Christoffels, 2016)
GO:0007507	Heart development	1067 (356)	200 (Pashmforoush et al., 2004)	1023 (343)	177 (Hoogaars, 2004)
GO:0036302	Atrioventricular canal development	15 (Gaussin et al., 2002)	10 (Mommersteeg et al., 2007)	8 (Puskaric et al., 2010)	3 (3)
Total number of heart development GO annotations		1131 (373)	255 (Kreuzberg et al., 2009)	1038 (345)	183 (Hoogaars, 2004)

Comparison of the number of CCS and heart development manual GO annotations associated with all human gene products (All) and 35 key CCS development proteins in March 2021 (end of project) versus October 2020 (start of project). The six listed GO terms were used as a GO slim to filter the annotations downloaded from QuickGO. Full details of the annotations can be found in Supplementary Table S2 and https://tinyurl.com/3259w2vc and https://tinyurl.com/3525rt4u. The number of manual annotations associated with the human gene products are listed, with the number of gene products associated with these terms in brackets. The IEA (Inferred from Electronic Annotation) annotations have not been included as this data is updated with each release.