TABLE 2.
A selection of GO annotations describing the role of murine Shox2 and Nkx2-5 in heart development.
| Protein | Qualifier | GO term | GO term identifier | Evidence code | Annotation extension | |
|---|---|---|---|---|---|---|
| Relation | Identifier | |||||
| Nkx2-5 | Involved in | Cardiac muscle cell development | GO:0055013 | IMP | — | — |
| NKx2-5 | Involved in | Cardiac muscle tissue morphogenesis | GO:0055008 | IMP | — | — |
| Shox2 | Acts upstream of | Regulation of heart rate | GO:0002027 | IMP | — | — |
| Shox2 | Involved in | Sinoatrial node development | GO:0003163 | IMP | — | — |
| Shox2 | Involved in | Sinoatrial node cell development | GO:0060931 | IMP | — | — |
| Shox2 | Involved in | Cardiac right atrium morphogenesis | GO:0003213 | IMP | — | — |
| Shox2 | Involved in | Cardiac pacemaker cell differentiation | GO:0060920 | IMP | Occurs_in | UBERON:0002351 |
| Part_of | GO:0003163 | |||||
| Shox2 | Involved in | Negative regulation of transcription by RNA polymerase II | GO:0000122 | IMP | Has_input | UniProtKB:P42582 |
| Occurs_in | UBERON:0002351 | |||||
A selection of the GO terms and annotation extension statements used to capture the role of Shox2 and Nkx2-5, as described by Espinoza-Lewis et al. (2009 and 2011) (Espinoza-Lewis et al., 2009; Espinoza-Lewis et al., 2011). These GO terms had not been previously associated with these proteins. Terms associated with the listed annotation extension identifiers: Uberon:0002351, sinoatrial node; GO:0003163, sinoatrial node development; UniProtKB:P42582, Nkx2-5.