TABLE 3.
Protein | Qualifier | GO term | GO term Identifier | Evidence code | With | Annotation extension | |
---|---|---|---|---|---|---|---|
Relation | Identifier | ||||||
Biological process | |||||||
TBX2 | Involved in | Endocardial cushion formation | GO:0003272 | IMP | — | — | — |
TBX2 | Involved in | Atrioventricular canal development | GO:0036302 | ISS | Q60707 murine Tbx2 | — | — |
TBX2 | Involved in | Atrioventricular canal morphogenesis | GO:1905222 | ISS | Q60707 murine Tbx2 | — | — |
TBX2 | Involved in | Cardiac jelly development | GO:1905072 | IMP | — | — | — |
TBX3 | Involved in | Sinoatrial node cell development | GO:0060931 | IDA | — | — | — |
TBX3 | Involved in | Endocardial cushion formation | GO:0003272 | IMP | — | — | — |
TBX3 | Involved in | Atrioventricular canal development | GO:0036302 | ISS | P70324 murine Tbx3 | — | — |
TBX3 | Involved in | Atrioventricular canal morphogenesis | GO:1905222 | ISS | P70324 murine Tbx3 | — | — |
TBX3 | Involved in | Cardiac jelly development | GO:1905072 | IMP | — | — | — |
TBX3 | Involved in | Cardiac epithelial to mesenchymal transition | GO:0060317 | IMP | — | — | — |
TBX3 | Involved in | Negative regulation of cell proliferation involved in heart morphogenesis | GO:2000137 | IMP | — | — | — |
TBX3 | Involved in | negative regulation of transcription by RNA polymerase II | GO:0000122 | IMP | — | Occurs in | UBERON:0000948 |
Part of | GO:0060317 | ||||||
TBX3 | Involved in | positive regulation of transcription by RNA polymerase II | GO:0000315 | IMP | — | Occurs in | UBERON:0000948 |
Part of | GO:0060317 | ||||||
Molecular function | |||||||
TBX3 | Enables | RNA polymerase II cis-regulatory region sequence-specific DNA binding | GO:0000978 | IDA | — | Occurs in | UBERON:0000948 |
TBX3 | Enables | DNA-binding transcription activator activity, RNA polymerase II-specific | GO:0001228 | IDA | — | Occurs in | UBERON:0000948 |
Part of | GO:0060317 | ||||||
TBX3 | Enables | DNA-binding transcription repressor activity, RNA polymerase II-specific | GO:0001227 | IDA | --- | Occurs in | UBERON:0000948 |
Part of | GO:0060317 |
Twenty GO annotations were created following the review of Singh et al. (2012) (Singh et al., 2012). Sixteen of these annotations describe the role of human TBX2 and TBX3 in heart development. Terms associated with the listed annotation extension identifiers: Uberon: 0000948, heart; GO:0060317, cardiac epithelial to mesenchymal transition.