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. 2022 Mar 2;13:802393. doi: 10.3389/fgene.2022.802393

TABLE 3.

A selection of GO annotations describing the role of human TBX2 and TBX3 proteins in heart development.

Protein Qualifier GO term GO term Identifier Evidence code With Annotation extension
Relation Identifier
Biological process
 TBX2 Involved in Endocardial cushion formation GO:0003272 IMP
 TBX2 Involved in Atrioventricular canal development GO:0036302 ISS Q60707 murine Tbx2
 TBX2 Involved in Atrioventricular canal morphogenesis GO:1905222 ISS Q60707 murine Tbx2
 TBX2 Involved in Cardiac jelly development GO:1905072 IMP
 TBX3 Involved in Sinoatrial node cell development GO:0060931 IDA
 TBX3 Involved in Endocardial cushion formation GO:0003272 IMP
 TBX3 Involved in Atrioventricular canal development GO:0036302 ISS P70324 murine Tbx3
 TBX3 Involved in Atrioventricular canal morphogenesis GO:1905222 ISS P70324 murine Tbx3
 TBX3 Involved in Cardiac jelly development GO:1905072 IMP
 TBX3 Involved in Cardiac epithelial to mesenchymal transition GO:0060317 IMP
 TBX3 Involved in Negative regulation of cell proliferation involved in heart morphogenesis GO:2000137 IMP
 TBX3 Involved in negative regulation of transcription by RNA polymerase II GO:0000122 IMP Occurs in UBERON:0000948
Part of GO:0060317
 TBX3 Involved in positive regulation of transcription by RNA polymerase II GO:0000315 IMP Occurs in UBERON:0000948
Part of GO:0060317
Molecular function
 TBX3 Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA Occurs in UBERON:0000948
 TBX3 Enables DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA Occurs in UBERON:0000948
Part of GO:0060317
 TBX3 Enables DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA --- Occurs in UBERON:0000948
Part of GO:0060317

Twenty GO annotations were created following the review of Singh et al. (2012) (Singh et al., 2012). Sixteen of these annotations describe the role of human TBX2 and TBX3 in heart development. Terms associated with the listed annotation extension identifiers: Uberon: 0000948, heart; GO:0060317, cardiac epithelial to mesenchymal transition.