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. 2022 Mar 2;10:830432. doi: 10.3389/fcell.2022.830432

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Copyright © 2022 An, Kuo and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of CPAP-E1235V mutant hiPSC clones. (A) Bright field colony morphology of CPAP-WT and two mutant cell clones. (B) Immunofluorescent staining and quantification for pluripotency markers: NANOG (green), OCT4 (red), and DNA (DPAI, blue). n = 64 for CPAP-WT; n = 37 for CPAP-E1235V#1; n = 36 for CPAP-E1235V#2. Data represent mean ±SEM. (C) Staining and quantified results of apoptosis marker TUNEL in WT and mutant hiPSC clones. n = 664 for CPAP-WT; n = 281 for CPAP-E1235V#1; n = 619 for CPAP-E1235V#2. Data are presented as the mean ±SEM from a pool of n cells from three independent experiments. n.s.: not significant; **p < 0.01; ***p < 0.001. Scale bar: 200 μm in (A), 20 μm in (B,C).