Table 3.
Study Participant Characteristics at Enrollment.
| Variables | Total (n = 540) | Cohort, median (IQR) | p-value | |
|---|---|---|---|---|
| D-dimer ≤6.53 (n = 270) | D-dimer > 6.53 (n = 270) | |||
| Baseline data | ||||
| Age, Median (Q1,Q3) | 64 (58, 70) | 63 (58, 69) | 64 (59, 70) | 0.144 |
| Gender, n (%) | 0.575 | |||
| female | 165 (31) | 79 (29) | 86 (32) | |
| male | 375 (69) | 191 (71) | 184 (68) | |
| BMI, Mean ± SD | 22.64 ± 3.16 | 22.62 ± 3.23 | 22.66 ± 3.1 | 0.881 |
| Pathological type, n (%) | 0.089 | |||
| Adenocarcinoma | 346 (64) | 161 (60) | 185 (69) | |
| Mixed lung cancer | 25 (5) | 13 (5) | 12 (4) | |
| Squamous carcinoma | 169 (31) | 96 (36) | 73 (27) | |
| Stage | 0.269 | |||
| I | 88 (16) | 52 (19) | 36 (13) | |
| II | 59 (11) | 30 (11) | 29 (11) | |
| III | 103 (19) | 47 (17) | 56 (21) | |
| IV | 290 (54) | 141 (52) | 149 (55) | |
| Smoking, n (%) | 0.605 | |||
| No | 261 (48) | 127 (47) | 134 (50) | |
| Yes | 279 (52) | 143 (53) | 136 (50) | |
| KPS, Median (Q1,Q3) | 90 (80, 90) | 90 (80, 90) | 90 (80, 90) | 0.133 |
| D-dimer, Median (Q1,Q3) (U/L) | 6.53 (3.94, 8.48) | 3.93 (2.85, 5.42) | 8.49 (7.4, 10.34) | <0.001 |
| Complications | ||||
| Hypertension, n (%) | 0.037 | |||
| No | 366 (62) | 49 (53) | 47 (76) | |
| Yes | 224 (38) | 44 (47) | 15 (24) | |
| Diabetes, n (%) | 0.323 | |||
| No | 533 (90) | 82 (88) | 57 (92) | |
| Yes | 57 (10) | 11 (12) | 5 (8) | |
| Hyperlipidemia, n (%) | 0.024 | |||
| No | 538 (91) | 88 (95) | 57 (92) | |
| Yes | 52 (9) | 5 (5) | 5 (8) | |
| Heart.failure, n (%) | 0.111 | |||
| No | 579 (98) | 89 (96) | 61 (98) | |
| Yes | 11 (2) | 4 (4) | 1 (2) | |
| ACS, n (%) | 0.813 | |||
| No | 575 (97) | 90 (97) | 60 (97) | |
| Yes | 15 (3) | 3 (3) | 2 (3) | |
| Outcomes | ||||
| Status, n (%) | <0.001 | |||
| alive | 174 (29) | 43 (46) | 23 (37) | |
| dead | 416 (71) | 50 (54) | 39 (63) | |
| Overall survival time, Median (Q1,Q3) | 24.17 (9.9, 50.99) | 38.9 (12.87, 59.8) | 18.05 (7.53, 50.99) | 0.012 |
| VTE events | <0.001 | |||
| 494 (91) | 260 (96) | 234 (87) | ||
| 46 (9) | 10 (4) | 36 (13) | ||
IQR, interquartile range; BMI, Body Mass Index; KPS, Karnofsky Performance Status; AQI, air quality index; ACS, Acute Coronary Syndromes; VTE, venous thromboembolism.