Table 4.

Bivariate and multivariate Cox regression of selected demographic and clinical characteristics for predictors of survival among children with retinoblastoma.

Variable	CHR (95% CI)	AHR (95% CI)	P value
Age group at first sign in months
0 to 12	1	1
13 to 36	1.08 (0.48 − 2.40)	0.89 (0.33 − 2.26)	0.772
Over 36	1.08 (0.45 − 2.58)	0.40 (0.14 − 1.13)	0.084
Sex: Male	1.04 (0.52 − 2.04)	1.12 (0.54 − 2.31)	0.769
Eye loss
No	1	1
1 eye enucleated	1.40 (0.67 − 2.94)	1.12 (0.51 − 2.45)	0.779
Both eyes enucleated	3.94 (1.64 − 9.46)	3.53 (1.33–9.36)	0.011
Metastatic spread
No	1	1
Yes	9.24 (3.88–22.02)	8.93 (3.23–24.69)	0.001
Lag time between first sign and UCI visit in months
0 to 6	1	1
7 and above	0.18 (0.07 − 0.42)	0.10 (0.04 − 0.25)	0.001
Proptosis
No	1	1
Yes	1.65 (0.82–3.31)	1.35 (0.52–3.48)	0.535
Eye swelling
No	1
Yes	2.62 (1.10–6.27)	4.39 (1.38–14.01)	0.012
Eye reddening
No	1	1
Yes	1.65 (0.73–3.70)	0.36 (0.14–0.94)	0.036