Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 2;13:761225. doi: 10.3389/fimmu.2022.761225

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Elkjaer, Röttger, Baumbach and Illes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Signatures of chronic active lesion in the WM lesion types in the MS brain based on transcriptome and proteome studies. Chronic active lesion has a different molecular profile in rim vs center. Most activity is present in the rim with stressed astrocytes and oligodendroglia, proinflammatory microglial polarization and foamy macrophages. Additionally, presence of coagulation factors and endothelial alterations are detected. The chronic active lesion displayed the highest number of neuronal/axonal intracellular components. The figure was created by compiling data from several articles, and therefore molecules may not be expressed at the same time. Created with BioRender.com.