Fig 1.

Study design. Potential risk period (dark blue) for vaccination cohorts was defined as time between the start of the vaccination campaign and one week before the end of data availability for each database (CPRD AURUM: 8 December 2020 to 2 May 2021; SIDIAP: 27 December 2020 to 23 June 2021). For the SARS-CoV-2 infected cohort, the potential risk period started on 1 September 2020. The baseline period for the self-controlled case series analysis (light blue) was defined from 1 January 2017 to 21 days before the day of vaccination or SARS-CoV-2 positive test result. The pre-risk period (pink) was defined as −21 to −1 days before vaccination or SARS-CoV-2 positive test result, and the risk period (orange) was defined as 1 to 21 days after vaccination and 1-90 days after a SARS-CoV-2 positive test result