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The trough concentrations of 116-N1 at day 5 and day 6 in multiple ascending-dose study.
| Concentration (ng/mL) | 200 mg (n = 9) | 400 mg (n = 9) | 600 mg (n = 9) |
|---|---|---|---|
| Pre-dose of 1st dosing at day 5 | 345 (88.2) | 766 (310) | 1011 (311) |
| Pre-dose of 2nd dosing at day 5 | 242 (56.9) | 559 (242) | 721 (272) |
| Pre-dose at day 6 | 326 (75.7) | 669 (262) | 924 (277) |
Note: Data are expressed as mean (SD).
