Table 1.

Role of m⁶A modifications in remodeling the tumor microenvironment

Regulators	Cancer type	Up- or down-regulated in tumor cells	Function	References
METTL3	TGCT	Down-regulated	Positively correlates with infiltration of CD8+ T cells, CD4+ T cells, and NK cells	[69]
METTL3	CRC	Up-regulated	Negatively correlates with infiltration of CD8+ T cells; Negatively correlates with IFN-γ, CXCL9, and CXCL10 secretion; Negatively correlates with the response to anti-PD-1 treatment	[70]
METTL3	CC	Up-regulated	Positively correlates with the density of CD33+ MDSCs	[71]
METTL3	BC	Up-regulated	Negatively correlates with infiltration of CD8+ T cells, helper T cells, and activated NK cells; positively correlates with infiltration of M2 TAMs	[72]
METTL3	HCC	Up-regulated	Negatively correlates with infiltration of DCs	[73]
METTL3 HNRNPC	HNSCC	Up-regulated	Positively correlates with the infiltration of CD4 naive T cells, CD4 memory-activated T cells and eosinophils	[74]
METTL14	BC	Down-regulated	Positively correlates with infiltrating levels of CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and DCs; negatively correlates with Treg cells	[77]
METTL14	ccRCC	Up-regulated	Negatively correlates with infiltration of Treg cells	[78]
WTAP	GC	Up-regulated	Negatively correlates with T cell infiltration and T cell-related immune responses	[79]
WTAP	EC	Up-regulated	Positively correlates with both the immuno-inhibitors and immuno-stimulators infiltration, such as myeloid DCs, T cells, neutrophils, Treg cells, and macrophages	[80]
FTO	AML	Up-regulated	Positively correlates with immune evasion, and inhibits the cytotoxicity of T cells	[85]
ALKBH5	Melanoma	unknown	Positively correlates with Treg cell infiltration; ALKBH5 deletion enhances the efficacy of anti–PD-1 therapy	[88]
ALKBH5	ICC	unknown	Positively regulates PD-L1 expression in tumor cells and inhibits the expansion and cytotoxicity of T cells by PD-1/PD-L1 signaling	[89]
YTHDF2	LGG	unknown	Positively correlates with infiltration of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and DCs	[92]
YTHDF1 YTHDF2	NSCLC	Up-regulated	Positively correlates with tumor-infiltrating lymphocytes, including CD8+ T cells, FOXP3+ T cells, PD-1+ T cells, and CD45RO+ immune cells	[93]
YTHDF2	KIRC	Down-regulated	Positively correlates with infiltration of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and DCs	[94]
YTHDF1	GC	Up-regulated	Negatively correlates with CD4+ cells and CD8+ T cells; positively correlates with MDSCs	[96]
YTHDF1	BC	Up-regulated	Negatively correlates with infiltration of CD4+ cells, CD8+ T cells, activated NK, and monocytes; positively correlates with infiltration of M1 macrophages	[97]