Table 5.
Adjusted effect of NT-proBNP on in-hospital death of patients with COVID-19 estimated through Cox proportional–hazard regression model
| Model | Adjusted HR | 95% CI | P value |
|---|---|---|---|
| NT-proBNP | |||
| Low | Reference | ||
| Medium | 3.41 | 1.22–9.51 | 0.02 |
| High | 3.88 | 1.30–11.57 | 0.01 |
| Sex | |||
| Female | Reference | ||
| Male | 3.28 | 1.75–6.12 | < 0.001 |
| Age | 1.01 | 0.99–1.02 | 0.26 |
| ICU Admission | |||
| No | |||
| Yes | 3.05 | 1.49–6.27 | 0.002 |
| History of CAD | |||
| No | Reference | ||
| Yes | 0.79 | 0.38–1.66 | 0.54 |
| History of HT | |||
| No | Reference | ||
| Yes | 0.37 | 0.14–1.02 | 0.055 |
| History of cancer | |||
| No | Reference | ||
| Yes | 0.96 | 0.40–2.99 | 0.93 |
| History of KD | |||
| No | Reference | ||
| Yes | 1.06 | 0.38–2.96 | 0.91 |
| History of Resp | |||
| No | Reference | ||
| Yes | 0.29 | 0.07–1.23 | 0.09 |
| History of DM | |||
| No | Reference | ||
| Yes | 0.73 | 0.43–1.23 | 0.24 |
| Severity | |||
| Non-severe | Reference | ||
| Severe | 3.32 | 1.59–6.97 | 0.001 |
| NT-proBNP*severity | 0.7 | 0.19–2.52 | 0.58 |
| WBC (103/µL) | 1.01 | 0.99–1.00 | 0.6 |
| BUN (mg/dL) | 1 | 0.99–1.01 | 0.0.22 |
| CRP (mg/L) | 1 | 0.84–1.19 | 0.99 |
| PCT (ng/mL) | 1.02 | 1.01–1.04 | 0.002 |
| Creatinine (mg/dL) | 0.99 | 0.84–1.18 | 0.96 |
| Troponin | |||
| Negative | |||
| Positive | 1.02 | 0.56–1.85 | 0.95 |