Table 4.
Association between BMD and Colorectal Neoplasms by Multivariate Logistic Regression Analysis
| Variable | Normal BMD (n=1,178), No. (%) | Osteopenia (n=792) | Osteoporosis (n=139) | |||||
|---|---|---|---|---|---|---|---|---|
| No. (%) | Adjusted OR (95% CI) | p-value | No. (%) | Adjusted OR (95% CI) | p-value | |||
| Adenoma | 457 (38.8) | 368 (46.5) | 1.21 (0.97–1.51) | 0.092 | 81 (58.3) | 1.65 (1.11–2.46) | 0.014 | |
| 3 or more adenoma | 75 (6.4) | 64 (8.1) | 1.17 (0.80–1.72) | 0.423 | 20 (14.4) | 2.05 (1.14–3.69) | 0.016 | |
| Advanced neoplasia* | 42 (3.6) | 35 (4.4) | 1.41 (0.85–2.32) | 0.183 | 8 (5.8) | 1.92 (0.82–4.49) | 0.133 | |
| High-risk adenoma† | 107 (9.1) | 88 (11.1) | 1.18 (0.85–1.65) | 0.322 | 25 (18.0) | 1.94 (1.14–3.29) | 0.014 | |
| SSL, TSA, or HP ≥10 mm | 70 (5.9) | 36 (4.5) | 0.80 (0.53–1.21) | 0.293 | 8 (5.8) | 1.04 (0.49–2.22) | 0.921 | |
Other covariates with p-values <0.1 in the univariate analyses were adjusted in the multivariate analyses.
BMD, bone mineral density; OR, odds ratio; CI, confidence interval; SSL, sessile serrated lesion; TSA, traditional serrated adenoma; HP, hyperplastic polyp.
*Advanced neoplasia was defined as (1) largest diameter ≥10 mm, (2) confirmed tubulovillous or villous histology, and (3) high grade dysplasia or invasive colorectal cancer; †High-risk adenoma was defined as (1) advanced neoplasia and (2) the presence of 3 or more adenomas.