Skip to main content
. 2021 Apr 24;18(2):466–479. doi: 10.5114/aoms/136070

Table IV.

Results of Mendelian randomization analysis for adrenic acid

Exposures MR Heterogeneity Pleiotropy
Method β SE P-value Method Q P-value Intercept SE P-value
Adrenic acid (22:4,n6)
 CHD MR Egger 0.068 0.525 0.908 MR Egger 1.818 0.402 0.012 0.013 0.445
WM 0.618 0.226 0.006
IVW 0.526 0.197 0.007 IVW 2.704 0.439
RAPS 0.537 0.206 0.009
 MI MR Egger 0.255 0.678 0.742 MR Egger 1.033 0.596 0.009 0.016 0.633
WM 0.639 0.282 0.023
IVW 0.606 0.255 0.017 IVW 1.344 0.718
RAPS 0.607 0.264 0.021
 FBG MR Egger 0.794 0.297 0.011 MR Egger 2.751 0.252 –0.0100 0.007 0.304
WM 0.445 0.113 8.5 × 10–5
IVW 0.417 0.127 1.0 × 10–3 IVW 5.335 0.148
RAPS 0.436 0.126 5.6 × 10–4
 TG MR Egger –1.149 0.539 0.0166 MR Egger 7.425 0.024 0.002 0.013 0.882
WM –1.082 0.156 4.7 × 10–12
IVW –1.064 0.149 1.2 × 10–12 IVW 7.529 0.056
RAPS –1.121 0.151 1.5 × 10–13
 TC MR Egger –1.149 0.539 0.016 MR Egger 7.425 0.024 0.002 0.013 0.882
WM –1.082 0.153 1.9 × 10–12
IVW –1.064 0.149 1.2 × 10–12 IVW 7.529 0.056
RAPS –1.124 0.151 1.5 × 10–13
 LDL-C MR Egger 0.220 0.572 0.073 MR Egger 6.738 0.034 0.015 0.014 0.391
WM 0.532 0.159 8.6 × 10–4
IVW 0.806 0.198 4.9 × 10–5 IVW 10.710 0.013
RAPS 0.709 0.184 1.2 × 10–4
 HDL-C MR Egger 0.955 0.334 0.010 MR Egger 2.656 0.264 –0.003 0.008 0.709
WM 0.858 0.130 4.2 × 10–11
IVW 0.820 0.097 4.3 × 10–17 IVW 2.900 0.407
RAPS 0.833 0.110 5.1 × 10–14
 Ischemic stroke MR Egger 0.059 0.616 0.931 MR Egger 0.4983 0.779 0.0040 0.0152 0.816
WM 0.197 0.261 0.450
IVW 0.210 0.234 0.370 IVW 0.568 0.903
RAPS 0.210 0.241 0.383
 Large artery MR Egger 2.499 2.029 0.343 MR Egger 3.459 0.173 –0.0215 0.050 0.709
WM 2.004 0.749 0.007
IVW 1.694 0.654 0.009 IVW 3.777 0.286
RAPS 1.706 0.697 0.014

WM – weighted median, IVW – inverse variance weighted, RAPS – robust adjusted profile score, SE – standard error, MR – Mendelian randomization, CHD – coronary heart disease, MI – myocardial infarction, FBG – fasting blood glucose, TG – triglyceride, TC – total cholesterol, LDL-C – low-density lipoprotein cholesterol, HDL-C – high-density lipoprotein cholesterol.