Table I.
Clinical parameters and serum concentrations of metalloproteinases, inflammatory cytokines, and cartilage turnover markers in the control and study group
| Parameter | Osteoarthritis (N = 25) | Control group (N = 32) | P-value |
|---|---|---|---|
| Mean age [years]* | 59.88 ±12.08 | 55.75 ±8.69 | 0.157 |
| Kellgren-Lawrence Grading (0–4)** | 3 (2, 4) | – | – |
| WOMAC score (0–100)* | 46.42 ±8.93 | – | – |
| Lequesne index (0–24)* | 10.31 ±2.29 | – | – |
| MMP-1 [ng/ml]* | 4.81 ±2.49 | 7.76 ±3.74 | 0.001 |
| MMP-3 [ng/ml]* | 23.34 ±29.22 | 9.18 ±3.06 | 0.002 |
| PG-AG [ng/ml]* | 4689.32 ±518.47 | – | – |
| IL-6 [pg/ml]* | 7.11 ±21.02 | 5.50 ±2.22 | < 0.001 |
| IL-18 [pg/ml]* | 106.00 ±189.76 | 16.73 ±16.99 | < 0.001 |
| YKL-40 [ng/ml]* | 88.98 ±72.29 | 44.31 ±17.50 | < 0.001 |
| IL-20 [pg/ml]* | 17.69 ±13.45 | 9.76 ±9.00 | 0.014 |
| COMP [ng/ml] | 2299.56 ±730.10 | 835.85 ±434.62 | < 0.001 |
*
The values are given as mean with standard deviation.
**
The values are given as median with interquartile range.