Table 2.
Tissue histological score in liver, kidney and heart of rats of control (C), sepsis (S), and meldonium + sepsis (M + S) groups: Liver Suzuki histological score (0–4) based on the sinusoidal congestion, vacuolization of hepatocyte cytoplasm and parenchymal necrosis (0—no changes; 1—minimal changes, 2—mild changes, 3—moderate changes, 4—severe changes); Renal histological score (0–4) based on the tubular epithelial cell flattening (TF), brush border loss (BBL), tubular necrosis (TN) and tubular lumen obstruction (TO) (0—no changes; 1—minimal changes, 2—mild changes, 3—moderate changes, 4 or above—severe changes); Heart histological score (Dallas criteria) based on the extent of inflammatory infiltration (II) (0—no changes; 1—mild changes, 2—moderate changes, 3—severe changes) and their distribution (1—focal; 2—confluent, 2—mild changes, 3—diffuse).
| Liver | C Group | S Group | M + S Group |
|---|---|---|---|
| Congestion | 1 | 2.71 | 1.25 |
| Vacuolization | 0.50 | 2.29 | 1.13 |
| Necrosis | 0.50 | 2.14 | 1.13 |
| Kidney | C group | S group | M+S group |
| TF | 4.25 | 7.57 | 6.38 |
| BBL | 4.13 | 12.29 | 11.50 |
| TN | 1.25 | 8.57 | 7.88 |
| TO | 0.00 | 9.86 | 6.38 |
| Heart | C group | S group | M+S group |
| II | 0.00 | 0.25 | 0.88 |
| Distribution | 0.00 | 0.25 | 0.63 |