Table 3.
Liver, kidney and heart lipidomics in rats of control (C), sepsis (S) and meldonium + sepsis (M + S) groups. L carnitine, triglycerides (TGAs), glycerol, total free fatty acid content (FFAs), glucose, lactate and inositol are expressed in mg/g, whereas concentrations of individual FFAs are expressed in μg/g. FFAs abbreviations: C14:0—myristic; C15:0—pentadecylic; C16:0—palmitic; C16:1—palmitoleic; C17:0—margaric; C17:1—heptadecenoic; C18:0—stearic; C18:1c—oleic; C18:1t—elidic; C18:2c+t—linoleic/linolelaidic; C18:3n3c+t—linolenic; C20—arachidic; C20:1—gondoic; C20:2—eicosadienoic; C20:3n3—dihomo-α-linolenic (ALA); C20:3n4—dihomo-γ-linolenic; C20:3n6—eicosahexaenoic; C22:6—docosahexaenoic (DHA). The number of animals per experimental group: n = 8. The data are given as mean ± standard error of the mean. Minimal significant level: p < 0.05. Significantly different: a with respect to the C group; b with respect to the S group. The number of animals per experimental group: n = 8. The data are given as mean ± standard error of the mean. Minimal significant level: p < 0.05. Significantly different: a with respect to the C group; b with respect to the S group.
| Liver | C Group | S Group | M + S Group |
|---|---|---|---|
| L carnitine | 0.575 ± 0.006 | 0.625 ± 0.005 a | 0.682 ± 0.004 a,b |
| TGAs | 1.054 ± 0.015 | 1.224 ± 0.005 a | 0.644 ± 0.010 a,b |
| Glycerol | 2.269 ± 0.014 | 2.665 ± 0.015 a | 2.908 ± 0.008 a,b |
| Total FFAs | 2.216 ± 0.137 | 2.487 ± 0.090 a | 2.880 ± 0.90 a,b |
| Glucose | 1.217 ± 0.002 | 1.091 ± 0.003 a | 1.078 ± 0.028 a |
| Lactate | 2.626 ± 0.021 | 2.777 ± 0.021a | 2.419 ± 0.009 a,b |
| Inositol | 0.610 ± 0.002 | 1.476 ± 0.013 a | 1.169 ± 0.029 a,b |
| C14:0 | 138.091 ± 0.849 | 147.201 ± 0.530 a | 169.343 ± 0.528 a,b |
| C15:0 | 18.815 ± 0.116 | 27.656 ± 0.099 a | 39.286 ± 0.091 a,b |
| C16:0 | 264.837 ± 1.628 | 231.321 ± 0.833 a | 263.097 ± 0.820 b |
| C16:1 | 60.166 ± 0.370 | 59.043 ± 0.210 | 60.523 ± 0.189 |
| C17:0 | 21.291 ± 0.130 | 29.235 ± 0.105 a | 28.149 ± 0.085 a |
| C17:1 | 15.813 ± 0.097 | 16.153 ± 0.059 | 15.991 ± 0.049 |
| C18:0 | 388.473 ± 2.389 | 425.616 ± 1.424 a | 496.444 ± 1.547 a,b |
| C18:1t | 191.625 ± 1.179 | 224.628 ± 0.772 a | 255.525 ± 0.797 a,b |
| C18:1c | 164.510 ± 1.013 | 191.591 ± 0.762 a | 236.689 ± 0.738 a,b |
| C18:2c+t | 325.322 ± 2.001 | 366.350 ± 1.283 a | 369.451 ± 1.151 a |
| C18:3n3c+t | 58.821 ± 0.361 | 58.657 ± 0.211 | 66.282 ± 0.206 a,b |
| C20 | 220.391 ± 1.355 | 254.474 ± 0.916 a | 296.440 ± 0.924 a,b |
| C20:1 | 34.304 ± 0.211 | 52.799 ± 0.189 a | 51.979 ± 0.162 a |
| C20:2 | 46.596 ± 0.286 | 70.005 ± 0.253 a | 71.599 ± 0.229 a |
| C20:3n3 | 21.751 ± 0.133 | 33.780 ± 0.121 a | 35.362 ± 0.110 a |
| C20:3n4 | 11.974 ± 0.073 | 23.725 ± 0.085 a | 23.824 ± 0.074 a |
| C20:3n6 | 23.334 ± 0.144 | 30.689 ± 0.110 a | 31.024 ± 0.097 a |
| C22:6 | 210.238 ± 1.293 | 275.059 ± 0.990 a | 376.264 ± 1.172 a,b |
| Kidney | C group | S group | M+S group |
| L carnitine | 0.623 ± 0.004 | 0.692 ± 0.001 a | 0.730 ± 0.002 a,b |
| TGAs | 0.492 ± 0.006 | 0.738 ± 0.005 a | 0.164 ± 0.002 a,b |
| Glycerol | 0.355 ± 0.002 | 0.783 ± 0.002 a | 0.977 ± 0.009 a,b |
| FFAs | 1152.978 ± 3.261 | 1330.299 ± 3.053 a | 1603.681 ± 7.077 a,b |
| Glucose | 0.732 ± 0.002 | 0.671 ± 0.003 a | 0.687 ± 0.002 a |
| Lactate | 2.462 ± 0.011 | 3.236 ± 0.009 a | 2.932 ± 0.011 a,b |
| Inositol | 0.362 ± 0.002 | 0.859 ± 0.005 a | 0.695 ± 0.002 a,b |
| C14:0 | 66.987 ± 0.189 | 81.855 ± 0.188 a | 96.851 ± 0.427 a,b |
| C15:0 | 8.126 ± 0.023 | 10.325 ± 0.023 a | 14.555 ± 0.065 a,b |
| C16:0 | 138.451 ± 0.391 | 166.398 ± 0.383 a | 185.056 ± 0.817 a,b |
| C16:1 | 34.176 ± 0.097 | 42.641 ± 0.098 a | 55.385 ± 0.244 a,b |
| C17:0 | 13.323 ± 0.037 | 16.809 ± 0.039 a | 19.824 ± 0.088 a,b |
| C17:1 | 8.669 ± 0.024 | 11.440 ± 0.026 a | 15.863 ± 0.070 a,b |
| C18:0 | 198.424 ± 0.561 | 216.048 ± 0.497 a | 319.694 ± 1.146 a,b |
| C18:1t | 94.951 ± 0.269 | 103.939 ± 0.239 a | 137.438 ± 0.607 a,b |
| C18:1c | 84.793 ± 0.239 | 97.285 ± 0.223 a | 123.254 ± 0.544 a,b |
| C18:2c+t | 164.795 ± 0.466 | 190.118 ± 0.438 a | 211.336 ± 0.933 a,b |
| C18:3n3c+t | 33.525 ± 0.095 | 37.895 ± 0.084 a | 43.130 ± 0.190 a,b |
| C20 | 114.894 ± 0.325 | 124.500 ± 0.285 a | 145.548 ± 0.642 a,b |
| C20:1 | 22.631 ± 0.064 | 28.770 ± 0.061 a | 34.097 ± 0.151 a,b |
| C20:2 | 25.598 ± 0.073 | 30.836 ± 0.064 a | 37.139 ± 0.164 a,b |
| C20:3n3 | 16.541 ± 0.047 | 21.163 ± 0.049 a | 20.906 ± 0.106 a |
| C20:3n4 | 9.804 ± 0.028 | 14.784 ± 0.033 a | 15.770 ± 0.069 a |
| C20:3n6 | 15.310 ± 0.043 | 19.079 ± 0.044 a | 26.214 ± 0.116 a,b |
| C22:6 | 101.980 ± 0.288 | 122.416 ± 0.281 a | 158.623 ± 0.700 a,b |
| Heart | C group | S group | M+S group |
| L carnitine | 0.884 ± 0.003 | 0.983 ± 0.004 a | 1.017 ± 0.004 a,b |
| TGAs | 0.467 ± 0.006 | 0.651 ± 0.005 a | 0.233 ± 0.003 a,b |
| Glycerol | 2.076 ± 0.007 | 1.952 ± 0.007 a | 1.274 ± 0.005 a,b |
| FFAs | 1512.182 ± 3.536 | 1402.85 ± 6.708 a | 1371.662 ± 7.284 a,b |
| Glucose | 0.792 ± 0.001 | 1.850 ± 0.002 a | 0.737 ± 0.003 a,b |
| Lactate | 4.398 ± 0.005 | 4.870 ± 0.019 a | 4.706 ± 0.010 a,b |
| Inositol | 0.467 ± 0.074 | 0.921 ± 0.003 a | 0.738 ± 0.001 a,b |
| C14:0 | 43.859 ± 0.010 | 35.237 ± 0.157 a | 28.021 ± 0.148 a,b |
| C15:0 | 4.610 ± 0.011 | 5.741 ± 0.0253 a | 4.559 ± 0.0265 b |
| C16:0 | 127.17 ± 0.291 | 120.423 ± 0.538 a | 121.225 ± 0.655 a |
| C16:1 | 40.896 ± 0.0925 | 33.153 ± 0.148 a | 24.578 ± 0.130 a,b |
| C17:0 | 14.158 ± 0.028 | 10.379 ± 0.045 a | 8.072 ± 0.048 a,b |
| C17:1 | 6.604 ± 0.013 | 4.431 ± 0.020 a | 3.299 ± 0.017 a,b |
| C18:0 | 196.863 ± 0.448 | 178.384 ± 0.841 a | 165.965 ± 0.961 a,b |
| C18:1t | 162.939 ± 0.348 | 149.855 ± 0.669 a | 134.488 ± 0.768 a,b |
| C18:1c | 103.710 ± 0.236 | 130.540 ± 0.583 a | 119.179 ± 0.632 a,b |
| C18:2c+t | 194.688 ± 0.421 | 180.918 ± 0.807 a | 166.481 ± 0.884 a,b |
| C18:3n3c+t | 49.210 ± 0.112 | 42.275 ± 0.189 a | 35.112 ± 0.186 a,b |
| C20 | 233.621 ± 0.509 | 207.710 ± 0.927 a | 197.160 ± 1.047 a,b |
| C20:1 | 53.837 ± 0.123 | 36.157 ± 0.161 a | 28.730 ± 0.153 a,b |
| C20:2 | 51.895 ± 0.119 | 50.704 ± 0.227 | 44.225 ± 0.235 |
| C20:3n3 | 42.273 ± 0.096 | 33.790 ± 0.160 a | 25.986 ± 0.137 a,b |
| C20:3n4 | 38.309 ± 0.088 | 29.691 ± 0.132 a | 20.218 ± 0.108 a,b |
| C20:3n6 | 33.590 ± 0.077 | 27.084 ± 0.130 a | 14.846 ± 0.078 a,b |
| C22:6 | 186.953 ± 0.425 | 212.379 ± 0.948 a | 211.119 ± 1.069 a |