Table 2.
All RTR (n = 480) | RTR with IFG excluded (n = 432) | ||||
---|---|---|---|---|---|
HR [95% CI] | P value | HR [95% CI] | P value | ||
Model 1 | Crude analysis | 2.27 [1.64–3.14] | < 0.001 | 2.21 [1.55, 3.17] | < 0.001 |
Model 2 | Adjusted for age and sex | 2.24 [1.62–3.11] | < 0.001 | 2.18 [1.52, 3.11] | < 0.001 |
Model 3 | Model 2 + BMI, systolic and diastolic blood pressure | 1.81 [1.29–2.53] | < 0.001 | 1.72 [1.18, 2.49] | 0.004 |
Model 4 | Model 2 + eGFR and time since transplantation, acute rejection, HLA class I and II antibodies | 2.34 [1.63–3.36] | < 0.001 | 2.0 [1.36, 2.94] | < 0.001 |
Model 5 | Model 2 + UACR | 2.23 [1.61, 3.09] | < 0.001 | 2.17 [1.52, 3.1] | < 0.001 |
Model 6 | Model 2 + plasma glucose, HbA1c | 1.80 [1.23–2.64] | 0.002 | 1.72 [1.14, 2.58] | 0.009 |
Model 7 | Model 2 + HDL cholesterol, LDL cholesterol | 1.68 [1.15–2.47] | 0.008 | 1.65 [1.09, 2.51] | 0.019 |
Model 8 | Model 2 + statin use | 2.23 [1.59–3.12] | < 0.001 | 2.09 [1.45, 3.02] | < 0.001 |
Model 9 | Model 2 + smoking and alcohol use | 2.33 [1.61, 3.38] | < 0.001 | 2.2 [1.46, 3.3] | < 0.001 |
Model 10 | Model 2 + use of proliferation inhibitors, calcineurin inhibitors, tacrolimus, cyclosporine and prednisolone dose | 2.14 [1.51–3.05] | < 0.001 | 2.09 [1.42, 3.06] | < 0.001 |
IFG impaired fasting glucose, BMI body mass index, eGFR estimated glomerular filtration rate, HLA human leukocyte antigen, UACR urinary albumin-to-creatinine ratio, HDL high density lipoprotein, LDL low density lipoprotein