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. 2022 Mar 16;21:41. doi: 10.1186/s12933-022-01475-y

Table 2.

Association of 1 mmol/l increase in RLP cholesterol levels with incident NODAT as determined by Cox regression analysis

All RTR (n = 480) RTR with IFG excluded (n = 432)
HR [95% CI] P value HR [95% CI] P value
Model 1 Crude analysis 2.27 [1.64–3.14]  < 0.001 2.21 [1.55, 3.17]  < 0.001
Model 2 Adjusted for age and sex 2.24 [1.62–3.11]  < 0.001 2.18 [1.52, 3.11]  < 0.001
Model 3 Model 2 + BMI, systolic and diastolic blood pressure 1.81 [1.29–2.53]  < 0.001 1.72 [1.18, 2.49] 0.004
Model 4 Model 2 + eGFR and time since transplantation, acute rejection, HLA class I and II antibodies 2.34 [1.63–3.36]  < 0.001 2.0 [1.36, 2.94]  < 0.001
Model 5 Model 2 + UACR 2.23 [1.61, 3.09]  < 0.001 2.17 [1.52, 3.1]  < 0.001
Model 6 Model 2 + plasma glucose, HbA1c 1.80 [1.23–2.64] 0.002 1.72 [1.14, 2.58] 0.009
Model 7 Model 2 + HDL cholesterol, LDL cholesterol 1.68 [1.15–2.47] 0.008 1.65 [1.09, 2.51] 0.019
Model 8 Model 2 + statin use 2.23 [1.59–3.12]  < 0.001 2.09 [1.45, 3.02]  < 0.001
Model 9 Model 2 + smoking and alcohol use 2.33 [1.61, 3.38]  < 0.001 2.2 [1.46, 3.3]  < 0.001
Model 10 Model 2 + use of proliferation inhibitors, calcineurin inhibitors, tacrolimus, cyclosporine and prednisolone dose 2.14 [1.51–3.05]  < 0.001 2.09 [1.42, 3.06]  < 0.001

IFG impaired fasting glucose, BMI body mass index, eGFR estimated glomerular filtration rate, HLA human leukocyte antigen, UACR urinary albumin-to-creatinine ratio, HDL high density lipoprotein, LDL low density lipoprotein