Fig. 3.

B. breve MCC1274 supplementation upregulates ADAM10 protein level in the hippocampus of App^NL-G-F mice. Protein levels of AβPP, ADAM10, BACE1, PS1, sAβPPα, sAβPPβ, and actin (A) and protein levels of total ERK, phosphorylated (p) ERK, total PKC, pPKC, HIF-1α, and actin (B) in the hippocampus were determined by western blot analysis, quantified by densitometry, normalized to actin level, and expressed as a value relative to the control. Data are expressed as the mean±SD, n = 7. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 compared with the vehicle group, n.s., no significant difference, as determined by Student’s t-test.