Fig. 2.

Percent reduction in plasma and CSF GL-1 levels after venglustat treatment. Mean percent change from baseline in plasma (A) and CSF (B) GL-1 levels in Japanese and non-Japanese participants who received placebo or were treated with venglustat (low, mid, or high dose) in Part 1 of the MOVES-PD trial. GL-1 levels were assessed in plasma samples collected at baseline, end of week 2, and end of week 4, and in CSF samples collected at baseline and end of week 4. ^aWeek 4 CSF sample was not collected for one participant from the non-Japanese population. CSF, cerebrospinal fluid; GL-1, glucosylceramide.