Table 5.

Annotated urine-based bladder cancer associated diagnostic

Full name	Abbreviation	Ascribed function	Location	Interacts with other members of signature
Interleukin 8	IL8	Chemoattractant & angiogenesis	Extracellular	MMP9, SDC1
Angiogenin	ANG	Angiogenesis	Extracellular, nucleus	None
Vascular endothelial growth	VEGFA	Angiogenesis	Extracellular, cytoplasm	None
factor A
Matrix metallopeptidase 9	MMP9	Breakdown of extracellular matrix	Extracellular	IL8, MMP10
Matrix metallopeptidase 10	MMP10	Breakdown of extracellular matrix	Extracellular	MMP9
Serpin peptidase inhibitor	SERPINA1	Serine protease inhibitor	Extracellular	None
Serpin peptidase inhibitor	SERPINE1	Serine endopeptidase inhibitor	Extracellular, plasma membrane	None
Carbonic anhydrase IX	CA9	Catalyze the reversible hydration of carbon	Plasma membrane	None
		dioxide
Apolipoprotein E	APOE	Lipoprotein catabolism and metabolism	Extracellular, plasma membrane,	None
			cytoplasm
Syndecan 1	SDC1	Cell binding, cell signaling, cytoskeletal	Plasma membrane, cytoplasm	IL8
		organization