Sadeghi 2007.

Methods	Prospective, randomised, double blinded study
Participants	Population: 67 patients undergoing hip fracture surgery Setting: Iran Date the study was conducted: 2004‐2005
Interventions	Intervention: tranexamic acid single bolus dose of 15 mg kg–1 administered intravenously at induction of anaesthesia Control: the same volume of saline solution was infused
Outcomes	Blood loss, blood transfusion, thrombotic complications and neurological deficits.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: Patients were randomised using a random number technique
Allocation concealment (selection bias)	Low risk	Quote: The correct treatment option was assured by means of coded infusion syringes prepared by hospital pharmacy not involved otherwise in the study
Blinding of outcome assessment (detection bias) Mortality	Low risk	Quote: Caring personnel both the staff of the operating room and the intensive care unit (ICU) were blinded regarding the type and nature of treatment
Blinding of outcome assessment (detection bias) Transfusion	Low risk	Quote: Caring personnel both the staff of the operating room and the intensive care unit (ICU) were blinded regarding the type and nature of treatment
Blinding of outcome assessment (detection bias) Complications	Low risk	Quote: Caring personnel both the staff of the operating room and the intensive care unit (ICU) were blinded regarding the type and nature of treatment
Incomplete outcome data (attrition bias) Mortality	Unclear risk	Not reported
Incomplete outcome data (attrition bias) Transfusion	Unclear risk	Not reported
Incomplete outcome data (attrition bias) Complication	Unclear risk	Not reported
Selective reporting (reporting bias)	Unclear risk	No protocol available
Other bias	Unclear risk	‐