. Author manuscript; available in PMC: 2022 Mar 16.

Published in final edited form as: Biochemistry. 2019 Nov 20;58(49):4983–4996. doi: 10.1021/acs.biochem.9b00863

Table 3.

Transcription factor binding motif enrichment in genes for proteins with significantly higher abundance in VWA8 null cells.

Transcription factor	Bonferroni P	Protein fold difference	Significance of Protein Difference

HnfG	3.52 E-11	ND
HnfA	6.90 E-11	3.8	0.01
NR2F1	3.14 E-07	1.19	NS
RXRB	1.15 E-05	1.07	NS
RXRA	1.32 E-05	2.67	0.05
CEBPA	2.28 E-05	ND
NR2F6	2.46 E-05	1.3	NS
SP1	9.66 E-05	0.67	0.05
SP2	1.06 E-04	0.67	0.05

Transcription factor binding motif analysis was performed using the −950 to +50 base 5’ untranslated regions of the genes coding for proteins that were significantly higher in VWA8-null cells compared to wildtype. PScan software, with the JASPAR 2016 database was used for analysis and statistical comparisons. Protein fold difference for VWA8 null compared to wild type cells are from proteomic results. ND = not detected in proteomic analysis.