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. 2022 Mar 2;9:849700. doi: 10.3389/fmed.2022.849700

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Copyright © 2022 Liu, Liu, Gan, He, Fu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of Meiboscore, MES, MQS and Lid margin abnormality score after punctal plugs insertion. (A) There was no statistically significant difference between the two groups in the mean meiboscores at baseline, 2 weeks, 2 and 6 months (P > 0.05, respectively). Compared with the baseline, the meiboscores did not change significantly at every visit in both groups. (B) The MES had no difference between the two groups at baseline and every visit (all P > 0.05). Compared with the baseline, the MES was improved at 2 and 6 months in both groups (P < 0.05, respectively). (C) There was no obvious difference of MQS between the two groups at baseline and every visit (all P > 0.05). Compared with the baseline, the decrease of MQS was statistically significant only at 2 months in both groups. (D) There was no statistical difference in the scores of lid margin abnormalities at baseline and every visit between the two groups (P > 0.05). After punctal plugs insertion, compared with the baseline, lid margin abnormalities scores were significantly improved in non-SS group at 2 and 6 months (P < 0.05, respectively). While SS group showed statistical difference only at 2 months (P < 0.05). (*p < 0.05 in SS vs. baseline, ^#p < 0.05 in non-SS vs. baseline).