Figure 4.

TVB, a data-driven neuroinformatics tool, fusing individual brain imaging data with atlas data and state-of-the-art brain modeling, for personalized simulations of brain activity and clinical interventions. Generative brain models operationalize a causal hypothesis, which is evaluated against the patient’s own brain imaging data using variants of dynamical causal modeling such as Monte Carlo simulations (Hashemi et al., 2020, 2021; Sip et al., 2021; Vattikonda et al., 2021; https://www.humanbrainproject.eu/en/medicine/the-virtual-brain/).