Figure 2.

Electrical synapse location and strength contribute to coupling coefficient and asymmetry measured at the soma. A, Coupling coefficients measured from cell 1 to cell 2 for all sets of somatic and middle-compartment electrical synapses. Soma-soma synapses are in yellow, middle-middle synapses are in red, and both types of soma-middle synapses are orange with opposite coupling (M-S) indicated by darker shaded datapoints. B, As in A for somatic and distal synapse locations. C, As in A for middle and distal synapse locations; note overall decrease in coupling for more-distant synapses. D, Coupling coefficient ratio (cc₁₂/cc₂₁) for each synapse location and strength. Locations are grouped by effect; the top box shows GJs between matched compartments that are symmetric, as expected. In the middle box, the GJ was closer to the soma of cell 2, and thus cc₂₁ was larger. In the bottom box, the GJ was closer to the soma of cell 1, and thus cc₁₂ was larger. Asymmetry increased with difference between location of the GJ, and with proximity to the soma.