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. 2022 Mar 2;13:778419. doi: 10.3389/fneur.2022.778419

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Copyright © 2022 DeChellis-Marks, Wei, Ding, Wolfe, Krivinko, MacDonald, Lopez, Sweet and Kofler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Excitatory Neurons, Oligodendrocytes, and Endothelial Cell proportions are altered in AD+P. Cell type proportion differences between AD+P and AD–P were determined using MIND signature gene matrix (32). Excitatory neuron proportion was significantly reduced in AD+P subjects compared to AD–P (T = 2.27 df = 75, p = 0.026). Conversely, oligodendrocyte (T = −2.17, df = 76, p = 0.033) and endothelial cell (T = −1.93, df = 78, p = 0.057) proportions were increased in AD+P compared to AD–P. Proportions of astrocytes, microglia, and inhibitory neurons did not differ between groups (astrocyte T = −0.90, df = 73, p = 0.372 microglia T = −0.03, df = 67, p = 0.978; inhibitory neuron T = 1.40, df = 74, p = 0.166). *Indicates p < 0.05.