Table 1.
Demographic, clinical, and tissue characteristics of subjects with Alzheimer's disease with and without psychosis examined by RNA-sequencing.
| Variable |
Alzheimer's disease without psychosis (n = 33) |
Alzheimer's disease with psychosis (n = 47) |
||
|---|---|---|---|---|
| Mean or total | SD or % | Mean or total | SD or % | |
| Age (years) | 83.7 | ±7.3 | 82.0 | ±6.0 |
| Age at onset (years)a | 75.6 | ±8.0 | 72.1 | ±6.6 |
| Duration of illness (years)a | 8.1 | ±3.0 | 9.0 | ±3.3 |
| Postmortem interval (hours) | 6.3 | ±4.0 | 5.9 | ±3.9 |
| Tau area ratio | 0.1 | ±0.1 | 0.1 | ±0.1 |
| Microvascular lesion sum score | 0.3 | ±0.5 | 0.2 | ±0.4 |
| HLA-DR:Iba1 ratio | 0.5 | ±0.7 | 0.4 | ±1.3 |
| Sex | ||||
| Male | 21 | 63.6% | 28 | 59.6% |
| Female | 12 | 36.4% | 19 | 40.4% |
| Braak stage | ||||
| III | 5 | 15.2% | 5 | 10.6% |
| IV | 15 | 45.5% | 18 | 38.3% |
| V | 13 | 39.3% | 24 | 51.1% |
| APOE-4 status | ||||
| Positive | 17 | 51.5% | 29 | 61.7% |
| Negative | 16 | 48.5% | 18 | 38.3% |
| TDP-43 pathology | ||||
| Positive | 18 | 56.2% | 34 | 72.3% |
| Negative | 15 | 43.8% | 13 | 27.7% |
| Lewy body pathology b | ||||
| Positive | 12 | 36.4% | 30 | 63.8% |
| Negative | 21 | 63.6% | 17 | 36.2% |
| Microvascular lesion count | ||||
| 0 | 23 | 67.7% | 36 | 76.7% |
| ≥1 | 10 | 32.3% | 11 | 23.4% |
| Antipsychotic use | ||||
| Yes | 2 | 6.1% | 9 | 19.1% |
| No | 31 | 93.9% | 38 | 80.9% |
a
Data unavailable for one subject, Alzheimer's Disease Without Psychosis.
b
p <0.05.