Table 3.

Comparison of models of psychosis.

Model	Neuropathological covariates	Modules selected	Cell type proportion selected	R 2	AUC	95% CI for AUC
1	PHF-1 Tau TDP-43 pathology HLA-DR:Iba1 Microvascular lesion Vascular sum score	NA	NA	0.117	0.666	0.540–0.793
2	PHF-1 Tau TDP-43 pathology HLA-DR:Iba1 Microvascular lesion Vascular sum score	NA	Endothelial cells excitatory neurons oligodendrocytes	0.299	0.789	0.680–0.898
3	PHF-1 Tau TDP-43 pathology HLA-DR:Iba1 Microvascular lesion Vascular sum score	23	Endothelial cells excitatory neurons oligodendrocytes	0.675	0.923	0.866–0.980

Models were constructed using combinations of neuropathological covariates, cell type proportions, and co-expression modules to evaluate their impact on psychosis occurrence. Model 1 used only neuropathological covariates. Model 2 provided a modest improvement by incorporating cell type proportion estimations. Model 3, including neuropathological covariates, cell type proportions, and co-expression modules accounted for the largest percent of variance in occurrence of psychosis.