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. 2022 Mar 16;60(3):e02070-21. doi: 10.1128/jcm.02070-21

TABLE 2.

Symptom presence, symptom onset, and impact on activities in participants with and without lab-confirmed influenza

Overall (976) Influenza negative (774) Influenza positive (202) P
New or worsening: N (%)
 Fever 441 (45.2) 304 (39.3) 137 (67.8) <0.001
 Headache 672 (68.9) 522 (67.4) 150 (74.3) 0.075
 Cough 789 (80.8) 610 (78.8) 179 (88.6) 0.002
 Chills/shivering 402 (41.2) 270 (34.9) 132 (65.3) <0.001
 Sweats 352 (36.1) 250 (32.3) 102 (50.5) <0.001
 Sore throat 725 (74.3) 569 (73.5) 156 (77.2) 0.325
 Vomiting 153 (15.7) 111 (14.3) 42 (20.8) 0.033
 Runny nose 741 (75.9) 581 (75.1) 160 (79.2) 0.257
 Sneezing 577 (59.1) 466 (60.2) 111 (55.0) 0.203
 Fatigue 784 (80.3) 617 (79.7) 167 (82.7) 0.40
 Muscle or body aches 597 (61.2) 447 (57.8) 150 (74.3) <0.001
 Trouble breathing 313 (32.1) 235 (30.4) 78 (38.6) 0.031
 No symptoms 38 (3.9) 34 (4.4) 4 (2.0) 0.169
 Illness felt worse than a typical cold 569 (58.3) 410 (53) 159 (78.7) <0.001
Participant perceived illness as: <0.001
 Cold 524 (53.7) 459 (59.3) 65 (32.2)
 Flu 314 (32.2) 190 (24.5) 124 (61.4)
 Other 138 (14.1) 125 (16.1) 13 (6.4)
Symptom onset within: 0.044
 0.5 days 0 (0.0) 0 (0.0) 0 (0.0)
 1 day 372 (38.1) 289 (37.3) 83 (41.1)
 1.5 days 161 (16.5) 122 (15.8) 39 (19.3)
 2 days 96 (9.8) 85 (11.0) 11 (5.4)
 3 days 49 (5.0) 44 (5.7) 5 (2.5)
 4 days 10 (1.0) 8 (1.0) 2 (1.0)
 5 days 19 (1.9) 17 (2.2) 2 (1.0)
No answer 269 (27.6) 209 (27.0) 60 (29.7)
Activities impacted by illness: <0.001
 Not at all 85 (8.7) 78 (10.1) 7 (3.5)
 A little bit 334 (34.2) 294 (38.0) 40 (19.8)
 Somewhat 282 (28.9) 234 (30.2) 48 (23.8)
 Quite a bit 183 (18.8) 121 (15.6) 62 (30.7)
 Very much 92 (9.4) 47 (6.1) 45 (22.3)