Changes in clinical outcomes depending on the use of inhalers in patients who needed inhalers. (A) Chronic obstructive pulmonary disease (COPD) assessment test (CAT) score, (B) St. George’s Respiratory Questionnaire (SGRQ) score, (C) modified Medical Research Council (mMRC) dyspnea scale, (D) cough quality of life questionnaire (CQLQ) score, (E) EuroQol-5 dimension (EQ-5D) score, and (F) cough visual analogue scale (VAS) score. The analysis was carried out with 21 subjects who had airway diseases, positive result of induced sputum, or a high level of fractional exhaled nitric oxide. Increasing scores indicate worsening outcomes in CAT, SGRQ, CQLQ, VAS, and mMRC. Decreasing scores indicate worsening outcome in EQ-5D. Differences between the two groups were tested using repeated measures analysis of variance (RM-ANOVA). Visit 1, baseline; Visit 2, 3-month follow-up. ap < 0.05.