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. 2022 Feb 15;13(11):3082–3093. doi: 10.1039/d1sc06231j

List of reported granular hydrogels, composed of either monomers (monom.), oligomers (PEG) or biopolymers (biop.) as a function of their interaction type. The values of the average microgel size, the average polymer content, the storage modulus (G′), the compression modulus (Ecomp.) and the tensile modulus (Etens.) are reported as a function of the interaction type and microgel composition.

Interaction type Microgel composition Microgel size Polymer content G′ E c E t Ref.
(μm) (wt%) (kPa) (kPa) (kPa)
Covalent Radical polym. Biop. Ox. Alg-MA 300 2.5 1 — — 54
Gel-MA 140 20 1 100 30 41
Gel-MA 90 20 10 50 — 56
PEG 4-PEG-MAL-MA (20 kDa) 75 6.6 2.4 — — 55
Click Biop. HA-acryl. + di-SH 74 3.5 — 1.0 — 66
PEG 4-PEG-azide (10 kDa) + 8-PEG-alkyne (20 kDa) 10–100 10 — 2.1–3.3 — 78
Enzym. Biop. HA-acryl. + di-SH 74 3.5 — 0.9 — 66
HA-acryl. + di-SH 45 3.5 — 1.5 — 68
PEG 4-PEG-VS (20 kDa) + di-SH 30–150 5 0.3 — — 67
4-PEG-VS (20 kDa) + di-SH 100 4–12 0.5–2.6 — — 70
8-PEG-VS (20 kDa) + di-SH 100–107 3–12 0.5–13.5 — — 71
4-PEG-VS (20 kDa) + di-SH 100 5 0.65 — — 2
4PEG-VS (20 kDa) + di-SH 100 5 0.5 — — 77
4-PEG-MAL (10 kDa) + 4-PEG-SH (10 kDa) 38 1.8–2 — 9–18 — 75
Binder/additive Click Biop. HA-AdNB + di-SH. Binder: HA-CD/AdNB 45 3 6 — — 11
HA-NB + di-SH. Binder: 4-PEG-tetrazine (20 kDa) 86 2.5 0.2 — — 69
HA-NB + di-SH. Binder: 4-PEG-tetrazine (20 kDa) 86 3.5 1.0 — — 72
HA-NB + di-SH. Binder: 4-PEG-tetrazine (20 kDa) 126 9.7–15.0 0.3–2.0 1.6–4.5 — 73
HA-NB + di-SH. Binder: di-SH 100 2 — 5 — 43
PEG 2-PEG-NB (5–20 kDa) + 2-PEG-SH (3.4 kDa). Binder: 2-PEG-SH (3.4 kDa) 200 11.3–15.1 0.2–1.5 — — 44
2-PEG-NB (5–20 kDa) + 2-PEG-SH (3.4 kDa). Binder: 2-PEG-SH (3.4 kDa) 200–500 10–15 1 — — 76
NHS coupling Biop. Gel-NB + 2-PEG-SH (2 kDa). Binder: 4-PEG-NHS (20 kDa) 600 4 2 1.5 — 82
Matrix Biop. Gel-TG. Binder: gel-TG 120–300 5–15 — — 14.4–56.8 83
Coordination chemistry Supramolecular Biop. Carboxy-cellul. nanofibrils 10 1 0.7–1.0 — — 84
HA-MA-gallol. Binder: gallol + Ag+ — — 0.13 — — 13
Charged interactions Supramolecular Biop. Gel-MA + chito-MA 170 10 3.1 — — 52
Monom PnaSS + MPTC — 58 — — 4000 51
Inter. netw. Double. netw. Monom. PAMPS + PAM 10–200 — — 250 10
PAMPS + PAM 65 13.6–45.7 — — 20–570 14