Table 2.
Success | Failure | P | |
---|---|---|---|
Heart rate | |||
Before HFNC¥ (mean±SD) | 97.53±19.20 | 106.96±20.56 | 0.011* |
1 h after HFNC¥ (mean±SD) | 96.76±19.07 | 110.34±21.76 | <0.001* |
12 h after HFNC¥ | 94.06 (20.76) | 99.10 (22.12) | 0.268 |
Respiratory rate | |||
Before HFNC | 27 (23-30) | 30 (25-33) | 0.032* |
1 h after HFNC | 25 (22-30) | 28 (23-35) | 0.079 |
12 h after HFNC | 26.5 (22.25-30.75) | 28 (23-34) | 0.164 |
GCS upon ICU | 15 (14-15) | 15 (10-15) | 0.024* |
GCS 12 h after HFNC | 15 (15-15) | 15 (13.75-15) | 0.027* |
pH on day of HFNC | 7.44 (7.41-7.48) | 7.47 (7.43-7.5) | 0.029* |
PCO2 on day of HFNC | 4.43 (4.04-5.19) | 4.28 (3.72-4.98) | 0.284 |
HCO3 on day of HFNC | 22.8 (19.8-25.7) | 22.25 (19.88-26.38) | 0.925 |
Platelet upon ICU | 238 (152-299) | 163 (100.5-251) | 0.012* |
Na upon ICU | 137 (133-139) | 134 (130.5-137) | 0.011* |
Bilirubin on day of HFNC | 11.5 (9-19) | 16.5 (10-24.85) | 0.051 |
APACHE IV score | 62 (49-82) | 75 (60.05-106.5) | 0.002* |
APACHE IV risk | 0.18 (0.09-0.31) | 0.26 (0.14-0.62) | 0.003* |
ROX 1 h | 7.13 (5.98-9.47) | 6.93 (4.59-7.66) | 0.014* |
ROX 12 h | 7.39 (6.42-9.90) | 6.10 (4.73-8.06) | 0.014* |
Time from admission to HFNC | 1.01 (0.35-2.02) | 0.68 (0.17-0.68) | 0.422 |
HFNC duration (h) | 47 (25.47-72) | 18 (5.18-42.69) | <0.001* |
ICU stay (days) | 4.99 (3.40-7.06) | 10.97 (5.33-23.04) | <0.001* |
28-day mortality (%) | 0 | 31 (44.9) | <0.001* |
Cause of respiratory failure§ | 0.629 | ||
Oxygen modality before HFNC | 0.646 | ||
Time from admission to HFNC | 24.28 (8.32-48.43) | 16.3 (4.09-59.61) | 0.422 |
*Clinical significance P<0.05, §Categorical. Results shown as median (IQR) unless otherwise specified, n (%) ¥Mean±SD. HFNC: High-flow nasal cannula, GCS: Glasgow Coma Scale, ROX: Ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate, APACHE: Acute Physiology and Chronic Health Evaluation, IQR: Interquartile range, ICU: Intensive care unit, SD: Standard deviation