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. 2021 Dec 28;39(1):5–11. doi: 10.4103/lungindia.lungindia_122_21

Table 2.

Predictive factors for success of high-flow nasal cannula

Success Failure P
Heart rate
 Before HFNC¥ (mean±SD) 97.53±19.20 106.96±20.56 0.011*
 1 h after HFNC¥ (mean±SD) 96.76±19.07 110.34±21.76 <0.001*
 12 h after HFNC¥ 94.06 (20.76) 99.10 (22.12) 0.268
Respiratory rate
 Before HFNC 27 (23-30) 30 (25-33) 0.032*
 1 h after HFNC 25 (22-30) 28 (23-35) 0.079
 12 h after HFNC 26.5 (22.25-30.75) 28 (23-34) 0.164
GCS upon ICU 15 (14-15) 15 (10-15) 0.024*
GCS 12 h after HFNC 15 (15-15) 15 (13.75-15) 0.027*
pH on day of HFNC 7.44 (7.41-7.48) 7.47 (7.43-7.5) 0.029*
PCO2 on day of HFNC 4.43 (4.04-5.19) 4.28 (3.72-4.98) 0.284
HCO3 on day of HFNC 22.8 (19.8-25.7) 22.25 (19.88-26.38) 0.925
Platelet upon ICU 238 (152-299) 163 (100.5-251) 0.012*
Na upon ICU 137 (133-139) 134 (130.5-137) 0.011*
Bilirubin on day of HFNC 11.5 (9-19) 16.5 (10-24.85) 0.051
APACHE IV score 62 (49-82) 75 (60.05-106.5) 0.002*
APACHE IV risk 0.18 (0.09-0.31) 0.26 (0.14-0.62) 0.003*
ROX 1 h 7.13 (5.98-9.47) 6.93 (4.59-7.66) 0.014*
ROX 12 h 7.39 (6.42-9.90) 6.10 (4.73-8.06) 0.014*
Time from admission to HFNC 1.01 (0.35-2.02) 0.68 (0.17-0.68) 0.422
HFNC duration (h) 47 (25.47-72) 18 (5.18-42.69) <0.001*
ICU stay (days) 4.99 (3.40-7.06) 10.97 (5.33-23.04) <0.001*
28-day mortality (%) 0 31 (44.9) <0.001*
Cause of respiratory failure§ 0.629
Oxygen modality before HFNC 0.646
Time from admission to HFNC 24.28 (8.32-48.43) 16.3 (4.09-59.61) 0.422

*Clinical significance P<0.05, §Categorical. Results shown as median (IQR) unless otherwise specified, n (%) ¥Mean±SD. HFNC: High-flow nasal cannula, GCS: Glasgow Coma Scale, ROX: Ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate, APACHE: Acute Physiology and Chronic Health Evaluation, IQR: Interquartile range, ICU: Intensive care unit, SD: Standard deviation