Table 5.

Factors predicting deterioration during the hospital stay

	Deterioration during the hospital stay, OR (95% CI), P
	Model-1	Model-2
Age (Reference: 18-45 years)
<18 years	0.6 (0.3-1.3), 0.179	0.5 (0.1-2.0), 0.343
45-60 years	1.7 (1.3-2.3), <0.001	1.5 (1.0-2.2), 0.039
>60 years	2.6 (1.9-3.6), <0.001	1.8 (1.2-2.8), 0.006
Male (Reference: Female)	1.2 (0.9-1.5), 0.149	0.9 (0.7-1.3), 0.694
Primary condition (Reference: COVID)
Non-COVID	2.1 (1.2-3.8), 0.010	0.9 (0.4-2.2), 0.850
Mucor	2.1 (0.2-24.0), 0.546
Vaccinated	0.8 (0·6-1.1), 0.131	0.8 (0.6-1.1), 0.237
Time to admission from symptom onset (Reference: 1 week)
2 weeks	0.7 (0.5-0.8), 0.001	0.6 (0.4-0.8), 0.001
3 or more weeks	1.4 (0.8-2.5), 0.206	0.8 (0.4-2.0), 0.675
Asymptomatic	1.0 (0.3-3.7), 0.952	2.3 (0.1-40.0), 0.569
Comorbidities (Reference: No)
1	1.3 (1.1-1.7), 0.030	1.3 (0.9-1.9), 0.110
2 or more	1.5 (1.1-2.1), 0.005	1.4 (0.9-2.1), 0.147
Baseline COVID-19 severity (Reference: Mild)
Asymptomatic - No hypoxia	0.2 (0.1-0.8), 0.026	0.1 (0.0-2.2), 0.144
Moderate	2.4 (1.7-3.4), <0.001	1.6 (1.0-2.5), 0.055
Severe	3.1 (2.4-4.1), <0.001	1.1 (0.7-1.6), 0.678
Symptoms reported (Reference: No)
Fever	0.7 (0.5-0.9), 0.021
Dry cough	1.3 (1.0-1.7), 0.021	1.6 (1.2-2.2), 0.002
Lab parameters (Reference: No)
Thrombocytopenia		1.8 (1.2-2.6), 0.003
Leucocyte count (Reference: Normal)
Leukopenia		0.5 (0.3-0.8), 0.006
Leukocytosis		2.1 (1.5-3.0), <0.001
D-Dimer >500 (Reference: ≤500)		2.5 (1.8-3.4), <0.001
CRP high (Reference: Normal)		6.0 (2.8-13.0), <0.001
Creatinine >1.0 mg/dl		2.3 (1.5-3.3), <0.001

Model-1: Adjusting for baseline clinical parameters, Model-2: Model-1 plus baseline lab parameters·Age, gender and comorbidities are included in all models·Only symptoms and lab parameters with significant P value are included in these final models. OR: Odds ratio, CI: Confidence interval, CRP: C-reactive protein