Supplementary Table 1.

Logistic regression model for developing critical illness

	OR (95%CI), P
	Model-1	Model-2
Age (Reference: 18-45 years)
<18 years	0.8 (0.2-3.0), 0.765	-
45-60 years	1.9 (1.3-2.7), 0.001	2·3 (1·4-3.8), 0·002
>60 years	2.7 (1.8-4.1), <0.001	2·5 (1·5-4·4), 0·001
Male (Reference: Female)	1.3 (1.0-1.8), 0.055	1·3 (0·9-1·9), 0·240
Vaccinated	0.7 (0.5-1.0), 0.054	0·7 (0·4-1.0), 0·057
Symptom onset to hospitalization (Reference: 1 week)
2 weeks	0.7 (0.6-0.9), 0.040	0.8 (0.5-1.1), 0.158
3 or more weeks	2.3 (1.3-4.2), 0.006	1.1 (0.4-2.8), 0.830
Asymptomatic	1.3 (0.4-4.8), 0.695	7.4 (0.3-165.0), 0.206
Comorbidities (Reference: No)
1	1.4 (1.0-2.0), 0.027	1.5 (1.0-2.3), 0.080
2 or more	1.8 (1.3-2.6), 0.001	1.7 (1.1-2.7), 0.036
Baseline COVID-19 severity (Reference: Mild)
Asymptomatic - No hypoxia	0.2 (0.02-2.4), 0.213	0.03 (0.01-1.4), 0.074
Moderate	2.3 (1.2-4.3), 0.011	1.7 (0.8-3.6), 0.137
Severe	11 (6.7-17.0), <0.001	4.9 (2.8-8.8), <0.001
Symptoms reported (Reference: No)
Gastrointestinal	0.6 (0.4-1.0), 0.059	0.5 (0.2-1.0), 0.053
Lab parameters (Reference: No)
Leucocyte count (Reference: Normal)
Leukopenia		0.6 (0.3-1.5), 0.303
Leukocytosis		2.1 (1.5-3.1), <0.001
Thrombocytopenia <1.5 lac (Reference: ≥1.5 lac)		2.5 (1.5-4.0), <0.001
D-Dimer >500 ng/ml (Reference: ≤500 ng/ml)		2.8 (1.9-4.0), <0.001
CRP >0.5 mg/dl (Reference: ≤0.5 mg/dl)		3.9 (1.1-13.0), 0.032
Creatinine >1.0 mg/dl (Reference: ≤1.0 mg/dl)		2.1 (1.4-3.2), 0.001

Model-1: Adjusting for baseline clinical parameters, Model-2: Model-1 plus baseline lab parameters·Age, gender and comorbidities are included in all models·Only symptoms and lab parameters with significant P value are included in these final models. OR: Odds ratio, CI: Confidence interval, CRP: C-reactive protein