Table 12. Concordance of F1CDx and an externally validated WES for TMB-High with ≥10 mut/Mb as cut-off.
| F1CDx+ /evWES+ |
F1CDx-/evWES+ | F1CDx+ /evWES- | F1CDx-/evWES- | PPA (95% CI) |
NPA (95% CI) |
|
|---|---|---|---|---|---|---|
| TMB ≥10 mut/Mb Set A |
28 | 7 | 4 | 50 | 80.00% (62.50, 90.62) |
92.59% (82.62, 98.04) |
| TMB ≥10 mut/Mb Set Ba |
23 | 1 | 17 | 88 | 92.31% (65.74, 100.0) |
90.84% (87.76, 93.99) |
CI = confidence interval; evWES = externally validated whole exome sequencing; F1CDx = FoundationOne®CDx; Mb = megabase; mut = mutation; NPA = negative percent agreement; PPA = positive percent agreement; TMB = tumor mutation burden.
s PPA and NPA were adjusted using the prevalence of TMB-high estimated at 19%.