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The influence of DHK on the rapid antidepressant effect of Ketamine. The crossing of mice in OFT (A); the immobility time of mice in day 1 (B); the immobility time of mice in day 2 (C). The data are expressed as means ± SEM, n = 10–12. **P < 0.01 compared with vehicle + vehicle + non-stressed group; ##P < 0.01 compared with vehicle + vehicle + CUMS group; @@P < 0.01 compared with ketamine + vehicle + CUMS group.
