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. 2022 Mar 2;16:789524. doi: 10.3389/fnbeh.2022.789524

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Copyright © 2022 Chen, Shen, Liu, Xu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The roles of AMPAR and L-VDCC played in the rapid antidepressant effect of Ketamine. The crossing of mice in an open field test in AMPAR blocked (A) and L-VDCC inhibition (C); the immobility time of mice in forced swimming test in AMPAR blocked (B) and L-VDCC inhibition (D). The data are expressed as means ± SEM, n = 10. ^**P < 0.01 compared with vehicle + vehicle + non-stressed group; ^##P < 0.01 compared with vehicle + vehicle + CUMS group; ^@@P < 0.01 compared with ketamine + vehicle + CUMS group.