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Immunological response of SARS-CoV-2 spike-specific memory T cells before and at 28th day post boost vaccination among four groups. Intracellular staining of cytokines in spike-specific CD8+ T cells (A) and spike-specific CD4+ T cells (B). (C) Th1/Th2 cytokine production by T cells using bead-based cytokine assay. (∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.005, ∗∗∗∗P < 0.001).
