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The effect of hypertension on the endothelium-dependent vasorelaxation of the thoracic aorta in 7-week-old (a), 20-week-old (b), and 52-week-old (c) rats. WKY: Wistar-Kyoto rats; SHR: spontaneously hypertensive rats. The results are presented as the mean ± SEM of n = 8–10 rats, and differences between groups were analyzed by two-way analysis of variance (ANOVA) with the Bonferroni post hoc test on ranks. ∗p < 0.05 vs. WKY.
