Table 1.
General biometric and cardiovascular parameters.
| WKY-7 | SHR-7 | WKY-20 | SHR-20 | WKY-52 | SHR-52 | |
|---|---|---|---|---|---|---|
| BW (g) | 144 ± 4 | 145 ± 5 | 359 ± 5+ | 350 ± 6+ | 447 ± 8+x | 426 ± 3+x∗ |
| SBP (mmHg) | 117 ± 1 | 160 ± 3∗ | 119 ± 3 | 204 ± 6+∗ | 126 ± 1+x | 198 ± 3+∗ |
| HR (bpm) | 479 ± 14 | 547 ± 9∗ | 463 ± 16 | 561 ± 13∗ | 483 ± 12 | 559 ± 17∗ |
| LV (mg) | 265 ± 11 | 308 ± 15 | 596 ± 16+ | 745 ± 25+∗ | 691 ± 16+x | 883 ± 19+x∗ |
| TL (mm) | 25.88 ± 0.24 | 25.81 ± 0.23 | 37.06 ± 0.16+ | 36.46 ± 0.14+∗ | 39.44 ± 0.20+x | 39.06 ± 0.09+x |
| LV/TL (mg/mm) | 10.21 ± 0.39 | 11.91 ± 0.50∗ | 16.09 ± 0.45+ | 20.42 ± 0.62+∗ | 17.52 ± 0.38+x | 22.60 ± 0.50+x∗ |
| LV/BW (mg/g) | 1.84 ± 0.08 | 2.08 ± 0.08∗ | 1.66 ± 0.05 | 2.13 ± 0.07∗ | 1.55 ± 0.05+ | 2.07 ± 0.05∗ |
BW: body weight; SBP: systolic blood pressure; HR: heart rate; LV: weight of the left heart ventricle; TL: tibia length; LV/TL: ratio of weight of the left heart ventricle to tibia length; LV/BW: ratio of weight of the left heart ventricle to body weight; WKY-7, WKY-20, and WKY-52: 7-week-old, 20-week-old, and 52-week-old Wistar-Kyoto rats; SHR-7, SHR-20, and SHR-52: 7-week-old, 20-week-old, and 52-week-old spontaneously hypertensive rats. The results are presented as the mean ± SEM of n = 9–14 rats, and differences between groups were analyzed by two-way analysis of variance (ANOVA) with the Bonferroni post hoc test on ranks. ∗p < 0.05 vs. WKY at the same age (WKY-7 vs. SHR-7, WKY-20 vs. SHR-20, and WKY-52 vs. SHR-52), +p < 0.05 vs. 7-week group of the same phenotype (WKY-20 vs. WKY-7, SHR-20 vs. SHR-7, WKY-52 vs. WKY-7, and SHR-52 vs. SHR-7), xp < 0.05 vs. 20-week group of the same phenotype (WKY-52 vs. WKY-20 and SHR-52 vs. SHR-20).