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. 2022 Mar 3;14:785761. doi: 10.3389/fnagi.2022.785761

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Copyright © 2022 Gao, Liu, Hou, Manaenko, Xiao, Wang, Xu and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neurons released mitochondria under the acidosis. (A) Schematic diagram describing the experimental procedure. (B) The presence of neuronal mitochondria in culture medium (CM) and mitochondria-depleted culture medium (mdCM) in both groups was analyzed by flow cytometry. (C) The neuronal mitochondria labeled with MitoTracker Green increased in CM treated with a pH 6.5 solution when compared with the pH 7.4 group, but decreased significantly in mdCM in both pH 7.4 and 6.5 groups. (D) The extracellular ATP increased significantly in CM after pH 6.5 treatment, but the ATP concentration decreased dramatically in mdCM after pH 6.5 treatment. n = 4. ***p < 0.001, ****p < 0.0001 vs. pH 7.4 CM; ^###p < 0.001, ^####p < 0.0001 vs. pH 6.5 CM.