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. 2022 Mar 3;14:785761. doi: 10.3389/fnagi.2022.785761

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Copyright © 2022 Gao, Liu, Hou, Manaenko, Xiao, Wang, Xu and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neurons released mitochondria under hydrogen peroxide (H₂O₂)-mediated oxidative stress and glutamate- and N-methyl-D-aspartate (NMDA)-induced excitotoxicity. (A) The experimental procedure. (B) The extracellular ATP increased dose-dependently in CM after H₂O₂ treatment. (C,D) The extracellular ATP increased significantly after treatment with NMDA (50 μM) or glutamate (100 μM). n = 4. *p < 0.05, ***p < 0.001 vs. control, ^#p < 0.05 vs. 25 μM H₂O₂.