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. 2022 Mar 3;14:785761. doi: 10.3389/fnagi.2022.785761

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Copyright © 2022 Gao, Liu, Hou, Manaenko, Xiao, Wang, Xu and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mRNA expressions of Miro1 and TFAM in astrocytes co-cultured with CM and mdCM from pH 7.4- and 6.5-treated neurons. The mRNA level of Miro1 (A) and TFAM (B) increased significantly in the CM from pH 6.5-treated group but no significant difference in the mdCM group. n = 6. *p < 0.05, ***p < 0.001 vs. pH7.4 CM; ^###p < 0.001 vs. pH 6.5 mdCM. CM, culture medium; mdCM, mitochondria-depleted CM; Miro-1, mitochondrial Rho GTPase 1; TFAM, mitochondrial transcription factor A.