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. 2022 Mar 17;3(4):262–268.e4. doi: 10.1016/j.medj.2022.03.004

Figure 2.

Figure 2

Tissue viral loads in hamsters on day 4 following SARS-CoV-2 infection

(A) E subgenomic RNA (sgRNA) levels in lung and nasal turbinates following infection of hamsters with SARS-CoV-2 WA1/2020, Beta, and Omicron variants (limit of detection 100 viral copies/g tissue).

(B) N genomic RNA (gRNA) levels in lung and nasal turbinates following infection of hamsters with SARS-CoV-2 WA1/2020, Beta, and Omicron variants (limit of detection 100 viral copies/g tissue).

(C) Weight loss at time of necropsy of hamsters in (A) and (B).

Data for WA1/2020 reflect N = 13 hamsters pooled from four different challenge experiments, data for Beta reflect N = 11 hamsters pooled from three different challenge experiments, and data for Omicron reflect N = 12 hamsters pooled from one experiment. Log sgRNA copies per gram tissue are shown. Medians (red bars) are depicted. p values represent two-sided Mann-Whitney tests.