Table 3.
Univariate analysis exploring the different risk factors for each infection
| BI Odds ratio (95%CI) |
CA-BI Odds ratio (95%CI) |
HAI Odds ratio (95%CI) |
|
|---|---|---|---|
| Male, gender | 1.266 (0.894–1.792) | 1.086 (0.749–1.575) | 1.870 (0.951–3.677) |
| < 3 months of age | 1.254 (0.845–1.861) | 1.232 (0.809–1.877) | 1.637(0.705–3.804) |
| Previous comorbidities | 0.981 (0.679–1.416) | 0.816 (0.548–1.216) | 2.4 (1.222–4.715) |
| Comorbidity’s types | |||
| Prematurity | 0.949 (0.631–1.427) | 0.934 (0.604–1.445) | 1.673 (0.817–3.428) |
| Respiratory | 0.310 (0.071–1.348) | 0.394 (0.090–1.719) | 0.932 (0.121–7.167) |
| Cardiologic | 1.173 (0.627–2.195) | 0.639 (0.294–1.389) | 3.186 (1.323–7.676) |
| Neurological | 1.740 (0.623–4.859) | 1.670 (0.571–4.885) | 1.189 (0.153–9.257) |
| BROSJOD > 12 | 2.470 (1.428–4.271) | 2.500 (1.422–4.396) | 2.013 (0.739–5.482) |
| Viral etiology | |||
| RSV | 0.806 (0.563–1.153) | 0.953 (0.648–1.400) | 0.441 (0.225–0.866) |
| Rhino/Enterovirus | 0.958 (0.639–1.437) | 0.862 (0.555–1.337) | 1.630 (0.796–3.338) |
| Metapneumovirus | 0.810 (0.321–2.040) | 1.037 (0.411–2.618) | 0.944 (0.927–0.962) |
| Influenza | 0.647 (0.262–1.600) | 0.504 (0.174–1.461) | 1.912 (0.554–6.603) |
| Viral co-infection | 0.689 (0.444–1.069) | 0.792 (0.500–1.253) | 0.837 (0.3599–1.951) |
| Bacterial co-infection | 2.454 (1.263–4.769) | 2.519 (1.278–4.964) | 0.985 (0.228–4.265) |
| Received treatment and support | |||
| Nebulized treatment | 0.781 (0.510–1.196) | 0.868 (0.549–1.372) | 0.504 (0.241–1.053) |
| Endotracheal mucolytic | 3.632 (2.261–5.834) | 3.234 (1.993–5.246) | 5.344 (2.612–10.931) |
| Inotropic support | 4.893 (3.160–7.575) | 4.354 (2.796–6.778) | 3.882 (1.916–7.865) |
| CMV | 4.015 (2.798–5.760) | 3.094 (2.122–4.509) | 8.344 (3.596–19.360) |
| CMV > 7 days | 2.867 (1.943–4.231) | 1.828 (1.207–2.767) | 11.361 (5.335–24.197) |
| Central line | 4.839 (3.352–6.985) | 3.683 (2.516–5.391) | 8.721 (3.902–19.492) |
| Central line > 7 days | 4.283 (2.912–6.300) | 3.050 (2.046–4.548) | 9.162 (4.392–19.114) |
| Urinary catheter | 4.001 (2.789–5.739) | 3.064 (2.102–4.464) | 8.524 (3.673–19.778) |
| Urinary catheter > 5 days | 3.840 (2.669–5.524) | 2.715 (1.858–3.967) | 10.984 (4.726–25.533) |
| ECMO | 2.890 (0.578–14.45) | 1.823 (0.331–10.052) | 19.273 (3.746–99.167) |
BI bacterial infection, CA-BI community-acquired invasive bacterial infection HAI hospital-acquired infection, BROSJOD bronchiolitis score of Sant Joan de Déu, CMV conventional mechanical ventilation, ECMO extracorporeal membrane oxygenation, RSV respiratory syncytial virus