Table 2.
Effect of intensive treatment on change in cerebral blood flow, white matter lesion volume, and total brain volume, stratified by baseline estimated glomerular filtration rate.
| MRI measure | Intensive | Standard | Difference in Change | P-value for interaction | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Baseline (95% CI) |
Follow-up (95% CI) |
Change (95% CI) |
Baseline (95% CI) |
Follow-up (95% CI) |
Change (95% CI) |
(95% CI) | ||
|
Total cerebral blood flow, (mL/100 g/min)
| ||||||||
| eGFR ≥60 | 36.64 (33.32, 39.96) | 38.23 (34.72, 41.74) | 1.58 (−0.08, 3.25) | 35.36 (32.02, 38.7) | 34.63 (31.11, 38.15) | −0.73 (−2.46, 1) | 2.32 (−0.07, 4.7) | 0.6 |
| eGFR <60 | 36.89 (32.93, 40.84) | 37.84 (33.68, 42.01) | 0.96 (−1.12, 3.04) | 37.78 (33.72, 41.83) | 35.35 (31.02, 39.69) | −2.42 (−4.67, −0.17) | 3.38 (0.32, 6.44) | |
|
WML volume, asinh (cm 3 ) | ||||||||
| eGFR ≥60 | 1.89 (1.75, 2.04) | 2.02 (1.87, 2.17) | 0.13 (0.08, 0.17) | 1.86 (1.71, 2.02) | 2.13 (1.98, 2.29) | 0.27 (0.22, 0.32) | −0.14 (−0.21, −0.07) | 0.2 |
| eGFR <60 | 2.28 (2.1, 2.46) | 2.49 (2.31, 2.68) | 0.21 (0.14, 0.28) | 2.12 (1.93, 2.3) | 2.39 (2.2, 2.58) | 0.27 (0.19, 0.34) | −0.06 (−0.16, 0.04) | |
|
Total brain volume, (cm 3 ) | ||||||||
| eGFR ≥60 | 1139.9 (1129.1, 1150.8) | 1109.5 (1098.6, 1120.4) | −30.4 (−32.5, −28.3) | 1138.9 (1127.9, 1149.9) | 1111.7 (1100.6, 1122.6) | −27.2 (−29.5, −24.9) | −3.2 (−6.3, −0.1) | 0.8 |
| eGFR <60 | 1112.2 (1097.8, 1126.6) | 1083.2 (1068.7, 1097.7) | −28.9 (−32.1, −25.9) | 1111.8 (1096.9, 1126.6) | 1086.6 (1071.7, 1101.5) | −25.2 (−28.4, −21.9) | −3.8 (−8.3, 0.7) | |
Interaction p-value is testing the difference in change between eGFR groups. Estimates are based on a linear mixed model adjusting for intracranial volume (except in CBF models) and days since randomization, with random effects for participant and MRI facility. Estimates represent least squares means, with follow-up estimated computed at 1452 days (3.98 years) post-randomization. For change estimates, negative values denote decreases from baseline, while positive values indicating increases from baseline. Difference in change represents intensive treatment group minus standard treatment group.
There were N=671, 713, and 716 participants included in the cerebral blood flow, WML volume, and brain volume analyses, respectively.
Abbreviations: asinh inverse hyperbolic sine transformation, f(x) = log(x + (x2 + 1)0.5), eGFR – estimated glomerular filtration rate, MRI – magnetic resonance imaging, SE - standard error, CI - confidence interval, WML - white matter lesion eGFR is expressed as ml/min/1.73m2